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Financial Toxicity Following Locally Advanced Rectal Cancer Treatment.

Dillon C Cheung1,2, Chi Zhang1,2, David Etzioni1

  • 1Department of Surgery, Mayo Clinic Arizona, Phoenix, Arizona.

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|March 9, 2026
PubMed
Summary
This summary is machine-generated.

Most patients with locally advanced rectal cancer experience financial toxicity, even with insurance. Open communication about treatment costs can help reduce this burden.

Keywords:
Financial burdenFinancial toxicityLocally advanced rectal cancerPatient-reported outcomes

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Area of Science:

  • Oncology
  • Health Economics
  • Patient-Reported Outcomes

Background:

  • Locally advanced rectal cancer (LARC) treatment involves significant costs.
  • The financial burden on patients undergoing LARC treatment is not well understood.

Purpose of the Study:

  • To determine the prevalence of financial toxicity in patients treated for LARC.
  • To identify factors predicting financial toxicity in this patient population.

Main Methods:

  • A multicenter retrospective cohort study was conducted.
  • A cross-sectional survey assessed patient-reported financial concerns and clinicodemographic data.
  • Patients treated for pathological stage II-III rectal adenocarcinoma between 2000-2019 were included.

Main Results:

  • Financial toxicity was reported by 86.7% of surveyed patients, most of whom had insurance.
  • Patients with financial toxicity experienced increased difficulty paying bills, decreased income, and challenges with transportation costs.
  • Taking unpaid leave for treatment increased the odds of financial toxicity, while being informed about costs decreased them.

Conclusions:

  • A high prevalence of financial toxicity exists among patients with LARC, irrespective of insurance status.
  • Direct and indirect costs associated with LARC treatment contribute significantly to financial strain.
  • Physician-patient communication regarding treatment economics is crucial for mitigating financial toxicity.