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[In₃O]-In Dual-Nodes-Based Metal-Organic Framework as a Self-Calibrating Luminescent Sensor for Rapidly Detecting

Jie Dong¹, Xiang Xiong¹, Man Yu¹

¹School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.

Inorganic Chemistry

|March 9, 2026

Summary

This study introduces a novel indium-based metal-organic framework (MOF) for sensitive and selective detection of sophocarpine. The developed MOF sensor offers a portable, instrument-free solution for clinical applications.

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Area of Science:

Materials Science
Analytical Chemistry
Nanotechnology

Background:

Sophocarpine detection is crucial due to its narrow therapeutic window and potential neurotoxicity.
Existing detection methods may lack the sensitivity or selectivity required for clinical settings.

Purpose of the Study:

To develop a highly sensitive and selective sensor for sophocarpine detection.
To create a portable, instrument-free detection platform for clinical use.

Main Methods:

Synthesis and characterization of an indium-based metal-organic framework (MOF) with a porous structure.
Fabrication of a composite film (MOF@CRG) for visual detection.
Evaluation of the sensor's sensitivity, selectivity, and recyclability for sophocarpine.

Main Results:

The MOF sensor exhibited high sensitivity with a low detection limit of 7.1 × 10⁻⁶ mol/L.
The sensor demonstrated excellent selectivity against interfering species and good recyclability.
A portable composite film enabled instrument-free visual detection of sophocarpine.

Conclusions:

This work presents the first MOF-based platform for sophocarpine detection.
The developed sensor offers a promising strategy for advanced clinical detection materials.
The portable film provides a practical solution for field-based sophocarpine monitoring.