Central giant cell granuloma and periapical fibrous dysplasia occurring in the same jaw

A 19-year-old woman presented with two tumorlike conditions in the mandible. Seven vital mandibular teeth were associated with periapical lesions. One periapical lesion was enucleated and histopathologic examination confirmed the diagnosis of periapical fibrous dysplasia. The second lesion was a large multilocular radiolucency which extended from the mandibular left premolars to the ascending ramus. It was diagnosed as a central giant cell granuloma despite having many features in common with those of an ossifying fibroma. The lesion was removed and healing was uneventful.