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Discovery of Coracanols A and B, Two Biological Nitrification Inhibition Diterpenoids from Finger Millet
Junnosuke Otaka1, Guntur Venkata Subbarao2, Shigeki Matsumiya3
1Biological Resources and Post-harvest Division, Japan International Research Center for Agricultural Sciences (JIRCAS), 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan.
Abstract:
Natural products with biological nitrification inhibition (BNI) activity released from plant roots show potential for increasing the nitrogen-use efficiency and decreasing the extent of environmental pollution. We isolated two diterpenoids, coracanols A (1) and B (2), from finger millet grown under low-nitrogen conditions. Both compounds showed BNI activity against nitrifying bacterium Nitrosomonas europaea. The novel skeletons (1 and 2) featuring a tetracyclo[10.2.2.01,10.02,7]hexadecane core were elucidated by spectroscopic and X-ray crystal structure analyses utilizing the crystalline sponge method.
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