Related Experiment Video
Updated: May 5, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.6K
A Systematic Review of Pediatric Acute Generalized Exanthematous Pustulosis
Ying Shan Cheung1, An Jian Leung1, Meiqi May Liau2
1Department of Medicine, National University Hospital, Singapore, Singapore.
Pediatric Dermatology
|March 9, 2026
Summary
Acute generalized exanthematous pustulosis (AGEP) in children is rare and severe. Medications commonly trigger AGEP in kids, with infections playing a larger role than in adults, guiding pediatric recognition and management.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacovigilance
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare but severe cutaneous adverse drug reaction.
- Pediatric AGEP is less understood than adult cases, necessitating specific research.
- Identifying triggers and effective management is crucial for improving outcomes in children.
Purpose of the Study:
- To systematically review cases of pediatric AGEP.
- To identify common triggers, clinical characteristics, and management strategies for AGEP in children.
- To provide data for early recognition and evaluation of pediatric AGEP.
Main Methods:
- Systematic review of 47 reported cases of pediatric AGEP.
- Analysis of patient demographics, causative agents, clinical presentation, and treatment outcomes.
- Comparison of findings with existing literature on adult AGEP.
Main Results:
- A male predominance was observed in pediatric AGEP cases.
- Medications were the most frequent trigger, with infectious etiologies contributing more significantly than in adults.
- Primary management involved drug cessation, topical corticosteroids, and supportive care.
Conclusions:
- Medications and infections are key triggers for pediatric AGEP.
- Effective management includes drug withdrawal, topical steroids, and supportive measures.
- Findings offer practical guidance for the clinical evaluation and management of children with AGEP.
Related Concept Videos
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
975
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
975
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
413
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
413
01:27Acne Infection
98
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
98