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Updated: Mar 11, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Requalification and Data Management of Pediatric Biological Samples Collected since 1984: A Case Study from a
Laure Sanvee-Edoh1, Kouamé Ambroise Kintossou2, Séverine Tabone-Eglinger1
1Plateforme de Gestion des Échantillons Biologiques, Centre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.
Introduction:
The Biological Sample Management Platform (PGEB) of the Centre Léon Bérard is responsible for the preparation, preservation, storage, and provision of the institution's sample collection. The PGEB was approached to integrate a neuroblastoma collection, one of the most common pediatric cancers. This collection was initiated through the diagnostic reference activity for neuroblastoma at the Centre Léon Bérard.
Objectives:
To requalify pediatric biological samples collected between 1984 and 2024 and to make them available for pediatric research protocols.
Methods:
This study began with an assessment of the data associated with each of the 21,389 samples in the collection. These data were then compared with relevant regulations and consensus documents related to biobank data management, as well as the minimum data requirements for research use. Based on this, a methodology for sorting samples-either for retention or disposal-was applied.
Results:
A set of minimum information criteria was established to revalue the samples. Various texts applicable in France mention the minimum data required for making samples available, but no consensus exists, either nationally or internationally. Furthermore, 65% of the samples met the criteria and were retained for future research use.
Conclusions:
This article describes the research work that led to the identification of minimum required data. However, further development is needed to harmonize practices regarding data management and interoperability.
