Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

β-Dicarbonyl Compounds via Crossed Claisen Condensations

β-Dicarbonyl Compounds via Crossed Claisen Condensations

Crossed Claisen condensations are base-promoted reactions between two different ester molecules producing β-dicarbonyl compounds. The reaction involving esters, with both containing α hydrogen, results in a mixture of four different products that are difficult to isolate. This reduces the synthetic utility of the reaction.

Preparation and Reactions of Thiols

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents

Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents

Carboxylic acids can be prepared by the carboxylation of Grignard reagents (RMgX). This method is convenient for converting alkyl (primary, secondary or tertiary), vinyl, benzyl, and aryl halides to carboxylic acids with one additional carbon than the starting RMgX.

Preparation of 1° Amines: Gabriel Synthesis

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...

Preparation of Carboxylic Acids: Overview

Preparation of Carboxylic Acids: Overview

There are various methods for the preparation of carboxylic acids. For example, oxidation of primary alcohols or aldehydes using strong oxidizing agents results in a carboxylic acid. Aldehydes can also be oxidized in the presence of mild oxidizing agents.

Carboxylic Acid Derivatives: Overview

Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modular Photochemical Approach to Access α-CF<sub>3</sub>-β-Aryl Carboxylic Acids via an Electron Donor-Acceptor Complex.

Organic letters·2026

Same author

TBAI-promoted synthesis of thioenamines <i>via</i> C-S bond formation between enaminones and thiosulfonates.

Organic & biomolecular chemistry·2025

Same author

Facile synthesis of 2-sulfonylbenzothiazoles <i>via</i> cascade SO<sub>2</sub><sup>-</sup>-NCS addition and S-C(sp<sup>2</sup>) coupling.

Chemical communications (Cambridge, England)·2025

Same author

Copper-Catalyzed One-Pot Synthesis of <i>N</i>,<i>N</i>-4-Triphenylthiazol-2-amines.

The Journal of organic chemistry·2024

Same author

Visible-light induced decarboxylative coupling of phenoxyacetic acid with disulfides: synthesis of α-arylthioanisole derivatives.

Chemical communications (Cambridge, England)·2024

Same author

Conversion of Acids to <i>S</i>-Alkyl Dithiocarbamates by Decarboxylative Sulfuration Using Visible-Light Photocatalysis.

Organic letters·2024

Same journal

Sulfonamides: a decade of development in synthetic methods and biological activity studies.

Organic & biomolecular chemistry·2026

Same journal

TBAF-promoted dephenolative transcarbomylation: direct access to substituted carbamates & thiocarbamates.

Organic & biomolecular chemistry·2026

Same journal

Catalytic synthesis of saturated azacycles using transborylation.

Organic & biomolecular chemistry·2026

Same journal

Pyridines with adamantane fragments and their 1,2,4-triazine analogues as anti-quorum-sensing agents, synthesis and molecular docking.

Organic & biomolecular chemistry·2026

Same journal

Synthesis of polymethylene-linked bis(cyclobutane-fused chromanones) mediated by gold photocatalysis.

Organic & biomolecular chemistry·2026

Same journal

Palladium-catalyzed chelation-assisted C-H functionalization of quinoline aldehydes to esters with mechanistic insights.

Organic & biomolecular chemistry·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

Recent progress on thiocarbamates: synthesis and applications.

Ao-Cheng Wang¹, Si-Yu Hu¹, Xin-Yu Lin¹

¹School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China. 124211726@qq.com.

Organic & Biomolecular Chemistry

|March 10, 2026

Summary

This summary is machine-generated.

This review highlights recent advances in thiocarbamate synthesis, covering diverse methods from thermochemistry to photochemistry and electrochemistry. It details the broad applications and mechanisms of these valuable organic compounds.

More Related Videos

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core

Published on: October 24, 2017

Related Experiment Videos

Last Updated: Mar 12, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core

Published on: October 24, 2017

Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Thiocarbamates are crucial organic molecules with diverse applications.
Their unique structure and properties drive interest in their synthesis.
Recent years have seen increased focus on developing new synthetic methodologies.

Purpose of the Study:

To summarize recent progress in effective thiocarbamate synthesis.
To highlight diverse synthetic strategies employed.
To discuss the applications and mechanisms of synthesized thiocarbamates.

Main Methods:

Review of synthetic strategies including thermochemistry, photochemistry, and electrochemistry.
Analysis of methodological advancements over the past decade.
Examination of product diversity and applicability.

Main Results:

Compilation of representative synthetic advancements in thiocarbamate chemistry.
Demonstration of the broad applicability of thiocarbamates in various fields.
Elucidation of reaction mechanisms for key synthetic routes.

Conclusions:

Thiocarbamate synthesis has seen significant methodological innovation.
These compounds exhibit wide-ranging utility in organic synthesis, materials science, and biomedicine.
Continued research promises further expansion of thiocarbamate applications.