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Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
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Real-World Weight Loss Is Associated With a Reduction in Cancer Risk.

Kenda Alkwatli1,2,3, Huijun Xiao2,4, Arshiya Mariam-Smith2,4

  • 1Endocrinology, Starling Physicians, Wethersfield, Connecticut, USA.

Obesity (Silver Spring, Md.)
|March 10, 2026
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Summary
This summary is machine-generated.

Nonsurgical weight loss significantly reduces the risk of developing obesity-related cancers and other cancer types. This study demonstrates a clear link between reduced body mass index (BMI) and decreased cancer incidence over time.

Keywords:
obesity/complicationsreal‐world datarisk reduction behavior

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Area of Science:

  • Oncology
  • Metabolic Health
  • Public Health

Background:

  • Obesity is a significant risk factor for various cancers.
  • The effect of non-surgical weight reduction on cancer risk requires further investigation.

Purpose of the Study:

  • To determine if real-world non-surgical weight loss is associated with a reduced risk of cancer diagnosis.
  • Evaluate the association between body mass index (BMI) changes and cancer risk.

Main Methods:

  • Retrospective observational study utilizing electronic health records from 2000-2022.
  • Included 143,630 adults with a BMI >= 30.
  • Generalized linear models assessed BMI change over 3-, 5-, and 10-year intervals against cancer risk.

Main Results:

  • Each 1% reduction in BMI was associated with a lower risk of obesity-related cancers at 3, 5, and 10 years.
  • Significant associations (p < 0.001) were observed for obesity-related cancers at 3 and 5 years.
  • Similar risk reductions were found for other cancer types across all time intervals.

Conclusions:

  • Real-world non-surgical weight loss is linked to a decreased risk of obesity-related cancers.
  • Weight loss also showed an association with reduced risk for other cancer types.
  • Findings support weight management as a strategy for cancer risk reduction.