Related Experiment Video
Updated: Mar 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Knee osteoarthritis classification using Optimized Granger Causality Inspired Graph Neural Network with Accelerated
M Ganesh Kumar1, L Bharathi2, M Senthil3
1Department of Electronics and Communication Engineering, QIS College of Engineering and Technology, Ongole, Andhra Pradesh, India.
Background:
Knee osteoarthritis (KOA) is a common, degenerative joint condition where cartilage wears away, causing bone-on-bone friction, leading to pain, stiffness, swelling, and reduced mobility, often with a cracking sound (crepitus). KOA affects the knee joint as a whole, and makes it difficult for the knee to move normally. In this paper, KOA classification using Optimized Granger Causality Inspired Graph Neural Network with Accelerated Model-agnostic Explanations and Secretary Bird Optimization Algorithm (KOAC-GCIGNN-AcME-SBOA) is proposed.
Methods:
The input images were collected from the Osteoarthritis Initiative (OAI) database. The images were then fed into the pre-processing stage with the help of Multi-Window Savitzky-Golay Filter (MWSGF) for artifact removal, resizing, contrast handling and normalization of the image. The pre-processed images were then fed into the feature extraction stage. The feature extraction was performed by Feature Affine Residual Network (FA-ResNet) to extract features such as mean, median, standard deviation, kurtosis and skewness. Finally, the extracted features were fed into GCIGNN-AcME for classifying KOA detection severity depending on four grades: Grade 0 (healthy), Grade 1 (doubtful), Grade 2 (minimal), Grade 3 (moderate) and Grade 4 (severe). Finally, SBOA was proposed to optimize the weight parameter of GCIGNN-AcME for KOA detection. Metrics, such as accuracy, precision, f1-score, sensitivity, specificity, receiver operating characteristic, and computational time were evaluated.
Results:
The KOAC-GCIGNN-AcME-SBOA attained 26.36%, 20.69%, 30.29% higher accuracy, 19.12%, 28.32%, 27.84% higher precision, 12.04%, 13.45%, 22.80% higher sensitivity compared with the existing methods: fully automated, fine-tuned deep learning method for the study of KOA progression (FAFT-CNN-KOD), KOA severity classification method with ordinal regression module (KAC-DNN-ORM), and KOA detection and classification method utilizing X-rays (KOD-CNN-XR), respectively.
Conclusion:
The proposed KOAC-GCIGNN-AcME-SBOA was successfully implemented.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
07:35A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
Related Concept Videos
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
Structural Classification of Joints
A fibrous joint is where the adjacent bones are united by fibrous connective...
Knee Joint
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...