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Long-Term Outcomes of Primary Cardiac Tumors by Histological Subtype
Mikio Shiba1,2, Masayuki Nishiyama3,4, Yohei Sotomi2,5
1Cardiovascular Division, Hyogo Prefectural Nishinomiya Hospital Hyogo Japan.
Circulation Reports
|March 11, 2026
Summary
Primary cardiac tumors have varying prognoses based on histology. Benign tumors like myxomas offer excellent outcomes, while malignant tumors such as diffuse large B-cell lymphomas (DLBCLs) are associated with early mortality.
Area of Science:
- Cardiovascular Pathology
- Oncology
- Surgical Outcomes
Background:
- Primary cardiac tumors are rare, and their prognostic impact based on histological subtypes is not well understood.
- Assessing clinical outcomes of benign and malignant cardiac tumors requires long-term follow-up data from pathologically confirmed cases.
Purpose of the Study:
- To evaluate the clinical outcomes and long-term prognosis of primary cardiac tumors based on histological subtypes.
- To compare the survival rates between benign and malignant primary cardiac tumors.
Main Methods:
- Retrospective analysis of 42 patients with primary cardiac tumors (2007-2022).
- Focus on 41 surgically resected patients with longitudinal follow-up.
- Assessment of clinical features, tumor distribution, and outcomes stratified by histological type.
Main Results:
- Myxomas (73%) showed excellent long-term outcomes with no recurrence or tumor-related deaths (median follow-up 12.8 years).
- Diffuse large B-cell lymphomas (DLBCLs) (7%) had uniformly poor outcomes, with all patients dying within 2 years.
- Other benign tumors (20%) also demonstrated favorable prognoses.
Conclusions:
- Benign cardiac tumors, particularly myxomas, are associated with favorable long-term outcomes.
- Malignant cardiac tumors, such as DLBCLs, are linked to early mortality, highlighting the prognostic significance of histological subtype.
