Integrating CRISPR/Cas technology with clinical trials: Principles, progress and challenges

Area of Science:

• Biotechnology
• Genomics
• Molecular Biology

Background:

• CRISPR gene editing technology has revolutionized genetic modification.
• Its application holds significant promise for treating genetic disorders, neurological diseases, infectious diseases, and cancer.

Purpose of the Study:

• To review current clinical trials utilizing the CRISPR/Cas system for various diseases.
• To emphasize innovative targeting strategies and therapeutic designs for CRISPR applications.
• To explore advancements in CRISPR editing efficiency, challenges, and future potential in managing genetic disorders and cancer.

Main Methods:

• Systematic review of current clinical trials involving CRISPR/Cas technology.
• Analysis of recent research focusing on CRISPR editing efficiency and therapeutic design.
• Examination of innovative targeting conditions and approaches for CRISPR-based therapies.

Main Results:

• CRISPR technology is rapidly expanding, with ongoing clinical trials exploring its therapeutic potential.
• Emphasis is placed on novel targeting strategies and functional therapeutic designs beyond traditional delivery methods.
• Research is actively increasing CRISPR editing efficiency for genetic disorders and cancer management.

Conclusions:

• CRISPR-based therapies show transformative potential for future medical treatments.
• Continued research into efficiency, targeting, and overcoming challenges is crucial for expanding clinical applications.
• This review provides a unique perspective on advancing CRISPR technology for improved patient outcomes.