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Published on: October 12, 2017
Effects of Ubiquinol on Oxidized Low-Density Lipoprotein in Prediabetic Patients: A Randomized, Double-Blinded,
Romun Leaovitavat1, Pasita Palakornkitti1, Paphitchaya Thetsana2
1Anti-Aging and Regenerative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand, dpu.ac.th.
Background/Objectives:
Oxidized low-density lipoprotein (oxLDL) has emerged as a promising biomarker of oxidative burden and cardiovascular risk. This study is aimed at evaluating the effect of ubiquinol supplementation, a potent lipophilic antioxidant, on oxLDL levels in prediabetic patients.
Methods:
This was a prospective, randomized, double-blinded, placebo-controlled pilot study of 20 adults with impaired fasting plasma glucose (FPG). Participants were randomized to receive either ubiquinol (100 mg/day) or placebo for 12 weeks. Plasma oxLDL levels were measured at baseline and Week 12.
Results:
After 12 weeks, the ubiquinol group demonstrated a significant within-group reduction in plasma oxLDL compared with baseline (p = 0.049), whereas no significant change was observed in the placebo group (p = 0.237). No adverse events were reported.
Conclusions:
Daily ubiquinol (100 mg/day) for 12 weeks was associated with a significant within-group decrease in plasma oxLDL among prediabetic participants; however, the between-group difference versus placebo was not significant.
Trial Registration:
Thai Clinical Trials Registry: TCTR20250512008.
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