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CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis.

Changye Yang1, Ruirui Yang2, Rundong Wang3

  • 1Department of Clinical Medicine, Affiliated Huishan Hospital of Xinglin College, Nantong University, No.2 Zhanqian North Road, Wuxi, 214000, Jiangsu, China, ntu.edu.cn.

Analytical Cellular Pathology (Amsterdam)
|March 11, 2026
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Summary

Coiled-coil domain-containing 97 (CCDC97) is highly expressed in cancers, correlating with poor prognosis and immune cell infiltration. CCDC97 shows promise as a prognostic and immunotherapy marker, especially in hepatocellular carcinoma (HCC).

Keywords:
CCDC97DNA methylationceRNA networkimmune cell infiltrationpan cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Coiled-coil domain-containing 97 (CCDC97) interacts with the SF3B splicing factor complex, influencing pre-mRNA splicing.
  • Disruptions in CCDC97's mechanism may contribute to cancer development, warranting further investigation.

Purpose of the Study:

  • To conduct a comprehensive cancer analysis of CCDC97.
  • To establish a competitive endogenous RNA (ceRNA) network for CCDC97.
  • To explore the oncogenic mechanisms underlying CCDC97's abnormal expression.

Main Methods:

  • Database searches for comprehensive cancer analysis of CCDC97.
  • Construction of a CCDC97-based ceRNA network.
  • Integration with known CCDC family oncogene mechanisms.

Main Results:

  • CCDC97 exhibits high expression across various cancers, linked to poor prognosis.
  • CCDC97 correlates with immune cell infiltration and immune checkpoints in the tumor microenvironment.
  • CCDC97 is highly expressed in hepatocellular carcinoma (HCC) tissues and associated with depleted T cells.

Conclusions:

  • CCDC97 serves as a potential prognostic and immunotherapy marker in cancers, particularly HCC.
  • Further experimental validation is required to confirm CCDC97's role.