Related Experiment Video
Updated: Mar 12, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Photo-Promoted Decarboxylative Arylation of 3-Indoleacetic Acids for the Synthesis of Indole-Containing
Jiaxin Wang1, Xiaofeng Wu1, Weiya Kong1
1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 South Shatai Road, Baiyun, Guangzhou 510515, People's Republic of China.
Abstract:
A visible-light-driven, photocatalyst-free C-C bond formation strategy is reported, enabling the decarboxylative arylation of 3-indoleacetic acid with (hetero)aromatic nitriles via electron donor-acceptor (EDA) complex activation. In addition, this strategy is also applicable to the coupling reaction between 3-indoleacetic acids and 2-sulfonylated benzothiazoles. Diverse indole-containing diarylmethanes were afforded in moderate to excellent yields. Moreover, biological evaluation revealed that several products exhibited antiproliferative activity against B16, HCT116, and HepG2 cancer cell lines. This protocol features mild conditions and a broad substrate scope and avoids external photocatalysts, offering a practical approach for constructing indole-based bioactive scaffolds.
More Related Videos
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
Related Concept Videos
Carboxylic Acids to Methylesters: Alkylation using Diazomethane
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction