Characterisation of the Novel HLA-DPA1*02:02:19 Allele by Sequencing-Based Typing
Marine Cargou1, Marco Andreani2, Tiziana Galluccio2
1CHU de Bordeaux, Laboratoire D'immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France.
HLA
|March 11, 2026
Summary
A novel HLA-DPA1*02:02:19 allele was identified, differing from the known HLA-DPA1*02:02:02:12 allele by a single nucleotide substitution. This finding contributes to the understanding of human leukocyte antigen diversity.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) research
Background:
- The human leukocyte antigen (HLA) system plays a critical role in immune response.
- Accurate HLA typing is essential for transplantation and disease association studies.
- Continuous discovery of novel HLA alleles refines our understanding of immune system diversity.
Purpose of the Study:
- To report the identification and characterization of a new HLA-DPA1 allele.
- To describe the specific genetic variation distinguishing this new allele from a known one.
Main Methods:
- Sequence-based typing of the HLA-DPA1 gene.
- Comparative analysis of nucleotide sequences to identify variations.
Main Results:
- A novel allele, HLA-DPA1*02:02:19, was identified.
- This allele differs from HLA-DPA1*02:02:02:12 by a single nucleotide substitution.
- The substitution is located in codon 4 within exon 2 of the HLA-DPA1 gene.
Conclusions:
- The identification of HLA-DPA1*02:02:19 expands the known HLA allele database.
- This specific nucleotide substitution highlights the fine-scale genetic variation within HLA loci.
- Further studies may explore the potential functional or clinical implications of this new allele.
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