Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

822
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
822
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

133.4K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
133.4K
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.7K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New Era of Precision Neuromodulation in Psychiatry.

JAMA psychiatry·2026
Same author

Corrigendum to "Revisiting subcallosal cingulate deep brain stimulation for depression: Long-term safety and effectiveness outcomes from a pooled analysis of 172 implanted patients" [Brain Stimul 18 (2025) 1632-1640].

Brain stimulation·2026
Same author

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.

Nature neuroscience·2026
Same author

Common Electrophysiology Biomarkers Collected at Home Robustly Track Depression Recovery With Deep Brain Stimulation.

medRxiv : the preprint server for health sciences·2026
Same author

Globus pallidus externus (GPe) alpha band activity decreases after deep brain stimulation in clinically responsive obsessive-compulsive disorder patients.

medRxiv : the preprint server for health sciences·2026
Same author

Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortium.

medRxiv : the preprint server for health sciences·2026
Same journal

Cognitive load modulates the effects of social contexts on facial expression processing.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

The neural mechanisms of aligning spatial perspectives.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Relationships between bilateral tapping skills and brain gray matter volumes: a voxel-based morphometry study.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Language laterality and cognitive skills: does anatomy matter?

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

The longitudinal development of intrinsic timescales in infancy and their relation to alpha brain rhythm.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same journal

Parietal thickness predicts middle temporal area (V5) motion responses in 7-year-old children born very preterm.

Cerebral cortex (New York, N.Y. : 1991)·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.5K

Ephaptic coupling and power fluctuations in depression.

Dimitrios A Pinotsis1, Sankaraleengam Alagapan2, Parisa Sarikhani2

  • 1Centre for Clinical, Social and Cognitive Neuroscience and Department of Psychology and Neuroscience, City St George's-University of London, London EC1V 0HB, United Kingdom.

Cerebral Cortex (New York, N.Y. : 1991)
|March 11, 2026
PubMed
Summary
This summary is machine-generated.

Deep Brain Stimulation (DBS) exposure shows lasting behavioral effects. New measures analyzing neural dynamics may predict depression symptom severity after DBS therapy.

Keywords:
DBSLyapunov exponentsdepressionelectric fields

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

681
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.6K

Related Experiment Videos

Last Updated: Mar 13, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

22.5K
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

681
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.6K

Area of Science:

  • Neuroscience
  • Computational Psychiatry
  • Biophysics

Background:

  • Deep Brain Stimulation (DBS) has acute behavioral effects that persist post-surgery.
  • Beta power fluctuations in local field potentials (LFPs) are potential biomarkers for DBS exposure in depression.
  • Neural dynamics underlying these power fluctuations require detailed investigation.

Purpose of the Study:

  • To investigate the relationship between brain power fluctuations and brain itinerancy after intraoperative DBS.
  • To introduce and validate novel dynamical systems measures for quantifying neural dynamics.
  • To explore the potential of these measures as biomarkers for depression symptom severity.

Main Methods:

  • Analysis of local field potential (LFP) data from the subcallosal cingulate cortex.
  • Application of two new dynamical systems measures: instability frequency and relative wandering time.
  • Correlation of measures with Hamilton Depression Rating Scale scores in a patient cohort.

Main Results:

  • Instability frequency and relative wandering time capture interactions between neural activity and mesoscale electric fields.
  • These novel measures showed potential in differentiating low vs. high Hamilton Depression Rating Scale scores.
  • The findings support the cytoelectric coupling hypothesis regarding altered electric fields in depression.

Conclusions:

  • Novel dynamical systems measures can describe neural dynamics related to brain itinerancy after DBS.
  • These measures may serve as biomarkers for depression symptom severity following DBS.
  • Further research is needed to confirm if these measures reflect general mechanisms of rapid antidepressant action.