Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.1K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

875
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
875
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

988
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
988
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

1.9K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
1.9K
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

1.9K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[From early detection to an integrated cross-setting treatment of young people with emerging affective and psychotic disorders].

Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen·2026
Same author

Assessing the generalisability of a multicentre qualitative dementia research: the experience and challenges faced by the MinD project in Europe.

Open research Europe·2023
Same author

Living Well with Dementia: Feeling Empowered through Interaction with Their Social Environment.

International journal of environmental research and public health·2023
Same author

Zeitschrift fur Gerontologie und Geriatrie·2023
Same author

An Investigation of the Wishes, Needs, Opportunities and Challenges of Accessing Meaningful Activities for People Living with Mild to Moderate Dementia.

International journal of environmental research and public health·2023
Same author

[Current aspects on the antipsychotic treatment of older people with schizophrenia spectrum disorders].

Zeitschrift fur Gerontologie und Geriatrie·2023

Related Experiment Video

Updated: Mar 13, 2026

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

702

[Multimodal treatment for depression in old age].

Vjera Holthoff-Detto

    Fortschritte Der Neurologie-Psychiatrie
    |March 11, 2026
    PubMed
    Summary

    Treating depression in older adults requires a personalized, multimodal approach. This strategy should target emotional, functional, and cognitive symptoms to improve overall health outcomes.

    Area of Science:

    • Gerontology
    • Psychiatry
    • Clinical Psychology

    Background:

    • Late-life depression significantly impairs daily functioning and accelerates cognitive and physical decline.
    • Older adults have reduced physiological and psychological resilience, complicating treatment.
    • Effective management of geriatric depression is crucial for maintaining quality of life.

    Purpose of the Study:

    • To outline a comprehensive, individualized treatment strategy for depression in the elderly.
    • To emphasize the need to address affective, functional, and cognitive domains concurrently.
    • To highlight the challenges in managing geriatric depression due to patient-specific vulnerabilities.

    Main Methods:

    • A multimodal treatment approach is recommended.

    More Related Videos

    Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
    07:12

    Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

    Published on: August 2, 2021

    4.3K
    Multi-Modal Home Sleep Monitoring in Older Adults
    07:40

    Multi-Modal Home Sleep Monitoring in Older Adults

    Published on: January 26, 2019

    8.3K

    Related Experiment Videos

    Last Updated: Mar 13, 2026

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
    10:54

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

    Published on: November 21, 2025

    702
    Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
    07:12

    Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

    Published on: August 2, 2021

    4.3K
    Multi-Modal Home Sleep Monitoring in Older Adults
    07:40

    Multi-Modal Home Sleep Monitoring in Older Adults

    Published on: January 26, 2019

    8.3K
  • Treatment plans should be tailored to the individual patient's needs.
  • Concurrent management of affective, functional, and cognitive symptoms is essential.

    • Main Results:

    • Individually tailored, multimodal interventions can effectively manage depression in older adults.
    • Addressing affective symptoms, functional status, and cognition holistically improves patient outcomes.
    • Successful clinical management requires consideration of the patient's limited somatic and psychological reserves.

    Conclusions:

    • A personalized, multimodal strategy is optimal for treating depression in old age.
    • Integrating the management of mood, function, and cognition is key to successful geriatric depression care.
    • Treatment must be adapted to the unique biological and psychological characteristics of elderly patients.