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Published on: October 25, 2016
Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis
Yeonjoo Kwak1, Bohyun Kim2, Jaekwon Seok1
1Stem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, 05029, Republic of Korea.
Abstract:
Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic condition with severe pelvic pain and urinary symptoms significantly impairing quality of life. This study investigated the clinical relevance of the metabotropic glutamate receptor (mGluR) family in IC/BPS. Bladder biopsy samples were taken from 61 patients, including 42 Hunner-type IC, 11 non-Hunner type IC, and 8 controls without IC. Gene expression analysis revealed that mGluR2, mGluR3, and mGluR5 were significantly elevated in patients with IC/BPS compared to controls. Among these, mGluR5 showed the strongest association with pain severity, fibrosis, and lymphoplasmacytic infiltration. Patients with Hunner-type IC also exhibited increased expression of p65 and interleukin-1β, suggesting activation of inflammatory response modulation in IC/BPS. These findings suggest that mGluR5 may contribute to pain through immune response modulation in IC/BPS. Targeting mGluR5 could represent a promising therapeutic strategy to alleviate symptoms and improve patient quality of life.
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