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Updated: Mar 13, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Engram Synapses and Synapse Dynamics in Memory Processing.

Yongmin Sung1, Chaery Lee1,2, Hyunsu Jung1

  • 1Learning and Memory Research Group, Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, South Korea.

Journal of Neurochemistry
|March 12, 2026
PubMed
Summary
This summary is machine-generated.

Memory formation involves synaptic plasticity, altering synapse strength and turnover dynamics. Engram synapses may serve as hubs for these changes, requiring further investigation into their formation and elimination.

Keywords:
learning and memorysynapsesynaptogenesis

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Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • Synaptic plasticity is fundamental to cognitive functions like learning and memory.
  • Memory formation involves changes in synapse strength and synaptic turnover dynamics.
  • Synaptic landscape changes reflect genetic alterations and molecular mechanisms of structural plasticity.

Purpose of the Study:

  • To review the relationship between synapse turnover dynamics and memory storage.
  • To summarize the molecular mechanisms underlying these synaptic changes.
  • To highlight the potential role of engram synapses in memory consolidation.

Main Methods:

  • Literature review and synthesis of existing research on synaptic plasticity and memory.
  • Analysis of studies investigating molecular mechanisms of pre- and postsynaptic plasticity.
  • Examination of evidence for activity-dependent synaptic changes in engram cells.

Main Results:

  • Memory storage is closely linked to the dynamic regulation of synaptic turnover.
  • Molecular mechanisms mediate both structural and functional synaptic plasticity.
  • Engram synapses across brain regions may act as central hubs for synaptic modifications during memory formation.

Conclusions:

  • The dynamics of synapse turnover are crucial for memory storage.
  • Understanding the molecular basis of synaptic plasticity is key to understanding memory.
  • Further systematic research is needed on the formation and elimination of engram-specific synapses across brain regions.