Site-Selective Decarboxylative C-H Carbenoid Functionalization Enabled by Pyridotriazole-3-carboxylates
Xin Yang1,2, Heng Xu1,2, Yi Dong1,2
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
None:
This paper describes a decarboxylative C-H carbenoid functionalization of (hetero)aryl carboxylic acids by using pyridotriazoles as the carbene precursors, which overcomes the limitation of ester group retention in conventional reactions, enabling the construction of diverse aza-tricyclic structural frameworks via a decarboxylative process. This method successfully overcomes the strong coordinative interference of L-type N-heterocycles with the metal catalyst, thereby allowing for highly site-selective C-H functionalization of (hetero)aryl acids.
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