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Transcriptome Analysis of Single Cells

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

Precision Delivery Using Nanopipette for Single-cell Studies.

He Zhang¹, Md Maksudur Rahman¹, Yang Tao¹

¹Department of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.

|March 12, 2026

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Nanopipettes offer non-contact imaging and precise delivery of molecules to single cells. This review explores nanopipette delivery methods and their impact on cell research, medicine, and pharmacology.

Area of Science:

Biotechnology
Nanotechnology
Cell Biology

Background:

Nanopipette scanning probe microscopy enables non-contact imaging in biological research.
Beyond topography, nanopipettes are increasingly used for localized delivery of bioactive molecules.

Purpose of the Study:

This mini-review highlights nanopipette applications in single-cell research, emphasizing localized delivery.
It summarizes and compares three delivery modes: resistive pulse, pressure-driven flow, and electroosmotic flow-driven delivery.

Main Methods:

Review of existing literature on nanopipette techniques for single-cell research.
Comparison of resistive pulse, pressure-driven flow, and electroosmotic flow-driven delivery principles.
Discussion of technical challenges and emerging applications in medicine and pharmacology.

Keywords:

Local delivery Nanopipette Scanning ion conductance microscopy Single cell image

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Related Experiment Videos

Last Updated: Mar 13, 2026

Transcriptome Analysis of Single Cells

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

A Pipette-Tip Based Method for Seeding Cells to Droplet Microfluidic Platforms

A Pipette-Tip Based Method for Seeding Cells to Droplet Microfluidic Platforms

Published on: February 11, 2019

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Main Results:

Nanopipettes provide versatile capabilities for both imaging and targeted molecular delivery at the single-cell level.
Three distinct delivery mechanisms (resistive pulse, pressure-driven, electroosmotic flow) are detailed and compared for their efficacy.
The review identifies current technical limitations in scanning ion conductance microscopy-based delivery.

Conclusions:

Nanopipette technology is a powerful tool for advancing single-cell research through precise molecular delivery.
Further development is needed to overcome technical challenges in scanning ion conductance microscopy-based delivery.
The applications of nanopipettes show significant promise for future medical and pharmacological research.