Related Experiment Video
Updated: Mar 13, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Osteoporosis and gut microbiota: current understandings
Yikai Liu1, Shuai Lu1,2, Ruifeng Bai3
1Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Abstract:
Osteoporosis (OP), a prevalent disease among middle-aged and elderly individuals, is characterized by a decrease in bone mineral density (BMD), which predisposes individuals to fragile fractures. The core pathological process involves excessive bone resorption over bone formation. The etiology of OP is intricate, and increasing recent studies have focused on the role of gut microbiota (GM) in its pathogenesis. Harmful bacteria exacerbate OP, whereas probiotics are beneficial for bone metabolism and delay the progression of OP. GM influences the progression of OP through various mechanisms, including the production of metabolites, modulation of the intestinal barrier, and regulation of intestinal immunity and osteoimmunology. In this review, we summarize the role of GM in the pathogenesis of OP based on the latest understandings, and highlight the promising potential of strategies targeting GM for the intervention and management of OP.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling
Osteoclasts in Bone Remodeling
What is Monogastric Digestion?
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

