Related Experiment Video
Updated: May 11, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
A Systematic Review on Insomnia and Circadian Rhythms Desynchronization in Obsessive-Compulsive Disorder: From
Grenno Giovanna1, Alfì Gaspare1, Miniati Mario2
1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Abstract:
Obsessive-compulsive disorder is frequently accompanied by sleep disturbances, particularly insomnia and circadian dysregulation. These conditions are increasingly recognised not only as comorbidities but also as factors potentially influencing the severity and course of obsessive-compulsive symptoms. This systematic review synthesises findings from 28 studies investigating the association between obsessive-compulsive disorder, insomnia and circadian alterations across different age groups. Insomnia was found to be highly prevalent among individuals with obsessive-compulsive disorder and associated with greater symptom severity, especially regarding intrusive thoughts and cognitive-affective dysregulation. Circadian disruptions, such as delayed sleep phase, evening chronotype, and atypical hormonal rhythms, were frequently observed and related to emotional instability and clinical variability. These results underscore the importance of systematically assessing and addressing sleep-related disturbances in patients with obsessive-compulsive disorder. Integrating sleep and circadian-focused strategies into clinical care may improve treatment outcomes and provide insight into underlying neurobiological mechanisms.
More Related Videos
08:36Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
Published on: August 8, 2019
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Related Concept Videos
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Management of Insomnia
Insomnia
Multiple factors contribute...
Obsessive-Compulsive Disorder
Oppositional Defiant Disorder
Diagnostic Criteria and...