para-Selective C-H Arylation and Alkylation of N-Arylhydroxylamines
Rui-Qiang Jiao1, Jingtai Pei2, Zhenguo Xi2
1School of Chemistry and Chemical Engineering, State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan, 750021, China.
Abstract:
The direct para-selective functionalization of arenes is difficult under mild conditions without the use of directing groups and transition-metal catalysts. Here we present a fluorosulfuryl imidazolium triflate-mediated direct para-selective C-H arylation and alkylation of N-arylhydroxylamines. This protocol exhibits a broad substrate scope and great functional-group adaptability. Moreover, the potential for scalable production and the feasibility of further modifications of the products showcase the practical utility of this method in synthetic applications.
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