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Concurrent Subacute Stent Thrombosis and Left Ventricular Thrombus After STEMI: A Therapeutic Dilemma
Juan D Palomar1, Carlos A Arias2, Jeffrey Castellanos2
1Programa de Cardiología-Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá, Colombia; Departamento de Medicina Interna, Clínica Universitaria Colombia, Clínica Colsanitas S.A., Grupo Keralty, Bogotá, Colombia.
Insights
Left ventricular thrombus (LVT) and stent thrombosis after myocardial infarction pose treatment challenges. This case used warfarin for anticoagulation, highlighting the need for individualized antithrombotic strategies.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Left ventricular thrombus (LVT) is a known complication of anterior ST-segment elevation myocardial infarction (STEMI) particularly after delayed reperfusion.
- The simultaneous occurrence of LVT and stent thrombosis presents a complex therapeutic dilemma with no established anticoagulation guidelines.
Background:
Left ventricular thrombus (LVT) is a complication of anterior ST-segment elevation myocardial infarction (STEMI) after delayed reperfusion. The coexistence of LVT and stent thrombosis represents a therapeutic challenge with no defined anticoagulation strategy.
Case Summary:
A 74-year-old man with anterior STEMI underwent rescue percutaneous coronary intervention with drug-eluting stents to the left anterior descending artery (LAD) and right coronary artery after 12 hours and was discharged on dual antiplatelet therapy. Three weeks later, he re-presented with severe chest pain and persistent ST-segment elevation. Coronary angiography demonstrated LAD stent thrombosis, treated with repeat angioplasty. Subsequent imaging revealed anterior-apical hypokinesia and a 10 × 6 mm apical LVT. Warfarin was added to dual antiplatelet therapy, achieving anticoagulation before discharge.
Discussion:
This case highlights limited evidence in the setting of coexisting LAD stent thrombosis and LVT after STEMI. Warfarin remains widely used, while data supporting direct oral anticoagulants are scarce.
Take-Home Message:
Individualized antithrombotic strategies balancing ischemic and bleeding risk are essential.
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