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Updated: Mar 13, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Healing Wounds
A Harrouet1, L Anger1, M Hautefeuille2,3
1Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.
None:
Wound healing has long provided a framework for studying cell and tissue dynamics, yet early contributions are often overlooked. Revisiting research from the late 19th to mid-20th centuries reveals enduring questions on migration versus proliferation, individual versus collective motion, and chemical versus mechanical drivers. Concepts such as contractility, collective motility, and contact inhibition illustrate the continuity of debate across generations. By reconnecting these foundational studies with modern advances, we highlight persistent gaps and offer historical context to guide future research.
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