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Illuminating the Invisible: Translational Molecular Imaging in Cardiovascular Medicine
Yan Ma1, Naiyuan Sun2, Yan Fang1
1Cardiology Department and National Clinical Research Center for Geriatric Diseases, Chinese Military Medical School, The Second Medical Center, Chinese PLA General Hospital, Beijing (Y.M., Y.F., Y.W., F.C.).
Circulation Research
|March 12, 2026
Summary
Molecular imaging offers advanced visualization of cardiovascular disease processes, detecting early molecular changes missed by conventional methods. This approach aids in risk stratification and personalized treatment for heart conditions.
Area of Science:
- Cardiovascular Medicine
- Molecular Imaging
- Biomedical Engineering
Background:
- Cardiovascular disease is a leading global health concern with increasing adverse outcomes.
- Conventional imaging lacks sensitivity for subclinical molecular changes preceding overt pathology.
Purpose of the Study:
- To review molecular imaging probes and platforms for cardiovascular disease.
- To assess their role in risk stratification and therapeutic monitoring.
- To explore AI and multiomics integration for precision cardiovascular medicine.
Main Methods:
- Critical appraisal of molecular probes (nanoparticles, antibodies, peptides) for target specificity, pharmacokinetics, and clinical use.
- Review of molecular imaging platforms (nuclear, MRI, CT, ultrasound, photoacoustic).
- Discussion of AI and multiomics in probe development and target validation.
Main Results:
- Molecular imaging visualizes in vivo disease processes like inflammation and metabolic dysregulation.
- Molecular imaging aids in assessing atherosclerosis, amyloidosis, cardiomyopathies, and remodeling.
- AI and multiomics accelerate probe development for precision medicine.
Conclusions:
- Molecular imaging represents a paradigm shift in cardiovascular medicine.
- It enables mechanistically informed, precision cardiovascular care.
- Enhanced diagnostics and therapeutics are anticipated through advanced molecular probes and AI integration.
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