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Updated: Mar 14, 2026
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Association between Helicobacter pylori infection and dyslipidemia: Evidence from observational studies and Mendelian
Fen Ren1, Caizheng Yang2, Hongwei Wang3
1Shanxi Medical University, No 56, Xinjian South Road, Yingze District, Taiyuan 030000, China.
Background:
Helicobacter pylori (H. pylori) infection is highly comorbid with dyslipidemia. This study investigated their association using longitudinal trajectory analysis and Mendelian randomization (MR).
Methods:
2433 individuals undergoing annual health examinations (2018-2021) were enrolled. Group trajectory modeling categorized subjects based on C14 breath test results into normal group, slow infection group and persistent infection group. Dyslipidemia incidence was tracked from 2022-2023. Log-rank tests compared incidence, and logistic regression calculated odds ratios (OR) with 95% confidence intervals (CI). Two-sample MR used H. pylori antibody GWAS data and UK Biobank dyslipidemia GWAS. Inverse Variance Weighted (IVW) was the primary method, supplemented by sensitivity analyses.
Results:
Three trajectories were identified. The incidence of dyslipidemia in slow infection group(23.2%) and persistent infection group (27.5%) was significantly higher than that in normal group (15.4%; P<0.05). After adjustment, compared with the normal group, the risk of dyslipidemia in the slow infection group and the persistent infection group increased by 0.759 times (95%CI: 0.541-1.066, P=0.012) and 1.752 times (95%CI: 1.169-2.625, P= 0.007) . MR analysis (IVW) showed H. pylori GroEL antibody levels significantly correlated with total cholesterol and HDL levels, and VacA antibody levels correlated with triglycerides (P < 0.05). Sensitivity analyses confirmed no heterogeneity or horizontal pleiotropy.
Conclusions:
Both longitudinal and MR analyses consistently demonstrate a significant association between persistent H. pylori infection and increased dyslipidemia risk. Further research into the underlying mechanisms is warranted to understand H. pylori's extragastric effects.
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