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Defect-Activated and Surface-Modified Hexagonal Boron Nitride Nanoparticles toward Intracellular Quantum Sensing.

Suzune Shimomura1, Yurina Nakane2, Hiroshi Abe3

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Hexagonal boron nitride nanoparticles with boron vacancy centers show promise as nanoscale quantum sensors. These modified nanoparticles offer enhanced stability and enable intracellular temperature sensing applications.

Keywords:
Optically detected magnetic resonanceboron vacancy centerintracellular sensingpolyglycerolquantum sensing

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Area of Science:

  • Quantum Sensing
  • Materials Science
  • Nanotechnology

Background:

  • Van der Waals materials with spin defects are a novel platform for quantum sensing.
  • Hexagonal boron nitride (hBN) nanoparticles offer potential for nanoscale quantum sensing applications.

Purpose of the Study:

  • To develop and characterize hBN nanoparticles with negatively charged boron vacancy (VB-) centers for quantum sensing.
  • To functionalize hBN nanoparticles for improved stability and reduced protein adsorption for biological applications.

Main Methods:

  • Generation of VB- centers in hBN nanoparticles using high-energy electron irradiation.
  • Two-step surface modification: silica encapsulation followed by hyperbranched polyglycerol (HPG) grafting.
  • Optically detected magnetic resonance (ODMR) for characterization and thermometry.

Main Results:

  • Efficient generation of VB- centers enabling clear ODMR detection.
  • HPG coating improved colloidal stability and reduced nonspecific protein adsorption.
  • ODMR thermometry demonstrated a thermal coefficient of approximately -300 kHz/°C.

Conclusions:

  • VB--containing hBN nanoparticles are effective nanoscale quantum sensors.
  • Surface modification enhances nanoparticle suitability for biological environments.
  • These sensors show potential for intracellular temperature sensing and other biomedical applications.