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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
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Desmoid tumours and their various presentations.

M L Nieto Morales1, C C Linares Bello1, J Martel Villagrán2

  • 1Servicio de Radiodiagnóstico, Complejo Hospitalario Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Radiologia
|March 12, 2026
PubMed
Summary
This summary is machine-generated.

Desmoid tumors are benign but locally aggressive, impacting quality of life. This review covers imaging findings and treatments, emphasizing a multidisciplinary approach for personalized care.

Keywords:
Aggressive fibromatosisBeta-cateninBetacateninaCrioablaciónCryoablationDesmoid tumourFibromatosis agresivaSarcomaTumor desmoide

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Area of Science:

  • Oncology
  • Radiology
  • Surgical Oncology

Background:

  • Desmoid tumors, though benign, exhibit aggressive local growth, significantly diminishing patient quality of life.
  • Current management lacks a treatment consensus, necessitating personalized strategies.
  • Multidisciplinary care and advanced imaging are crucial for effective diagnosis and treatment.

Purpose of the Study:

  • To review imaging findings of treated desmoid tumors over 15 years.
  • To discuss current treatment options for desmoid tumors.
  • To highlight the importance of a multidisciplinary approach in managing desmoid tumors.

Main Methods:

  • Retrospective review of imaging findings for desmoid tumors treated across two institutions over 15 years.
  • Analysis of various treatment modalities employed.
  • Evaluation of the role of image-guided techniques.

Main Results:

  • Detailed review of characteristic imaging findings in treated desmoid tumors.
  • Overview of the spectrum of treatment interventions, including surveillance, surgery, and pharmacotherapy.
  • Emphasis on the necessity of tailored management plans.

Conclusions:

  • Individualized treatment strategies are paramount for desmoid tumor management.
  • A multidisciplinary team approach is essential for optimal patient outcomes.
  • Advanced imaging plays a vital role throughout the patient journey.