Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Precise Cancer Anti-acid Therapy Monitoring Using pH-Sensitive MnO<sub>2</sub>@BSA Nanoparticles by Magnetic Resonance Imaging.

ACS applied materials & interfaces·2021

Same author

Effects of histone H4 hyperacetylation on inhibiting MMP2 and MMP9 in human amniotic epithelial cells and in premature rupture of fetal membranes.

Experimental and therapeutic medicine·2021

Same author

Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health.

Cell & bioscience·2021

Same author

Diluted-CdS Quantum Dot-Assisted SnO<sub>2</sub> Electron Transport Layer with Excellent Conductivity and Suitable Band Alignment for High-Performance Planar Perovskite Solar Cells.

ACS applied materials & interfaces·2021

Same author

A microporous surface containing Si<sub>3</sub>N<sub>4</sub>/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration.

Bioactive materials·2021

Same author

Clinical importance of ADC in the prediction of <sup>125</sup>I in the treatment for gliomas.

Journal of Cancer·2021

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Stealth designs to overcome allorejection in engineered cell therapy.

Yan-Ruide Li¹, Yuning Chen², Lili Yang³

¹Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Goodman-Luskin Microbiome Center, Los Angeles, CA 90095, USA.

Trends in Immunology

|March 12, 2026

Summary

Engineered

Keywords:

HLA ablation NK inhibitory ligands allorejection immune evasion multiplex genetic engineering stem cell engineering

More Related Videos

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

Published on: September 9, 2022

Related Experiment Videos

Last Updated: Mar 14, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

Published on: September 9, 2022

Area of Science:

Immunology
Cell Therapy
Genetic Engineering

Background:

Allogeneic engineered therapeutic cells face immune rejection.
Advances in immunology and genetic engineering are crucial for cell therapy development.

Purpose of the Study:

To describe strategies for creating 'stealth' allogeneic cells.
To highlight methods for evading immune detection while preserving cell function.

Main Methods:

Deletion of human leukocyte antigen (HLA) class I and II molecules.
Expression of natural killer (NK) cell inhibitory ligands.
Upregulation of CD47 to prevent phagocytosis.

Main Results:

'Stealth' cell designs effectively evade immune detection.
These strategies maintain therapeutic cell function.
Refined approaches utilize novel immune-modulatory molecules and assays.

Conclusions:

Stealth designs are advancing allogeneic cell therapy translation.
These strategies aim for more durable and broadly applicable clinical use.