Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nanocomplexes Integrated into a Polymeric Bilayer Film Enhance Buccal Permeation of a GLP-1 Peptide Analogue.

ACS applied materials & interfaces·2026

Same author

Oesophageal tissue screening system for assessing the retention and mucosal absorption of biologics.

Nature biomedical engineering·2026

Same author

The Use of Deep Learning in RNA Therapeutic Development.

ACS nano·2026

Same author

Editorial: Do we Need to Adapt GERD Metrics Based on the Population Being Evaluated? Authors' Reply.

Alimentary pharmacology & therapeutics·2026

Same author

Letter: From Regional Diagnostic Thresholds to Phenotype-Guided Management in Asian Reflux Disease. Authors' Reply.

Alimentary pharmacology & therapeutics·2026

Same author

The Aging Esophagus: Contraction Reserve on High-Resolution Manometry Declines With Age.

Neurogastroenterology and motility·2026

Same journal

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

Nature communications·2026

Same journal

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity.

Nature communications·2026

Same journal

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026

Same journal

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026

Same journal

Proton shuttling at electrochemical interfaces under alkaline hydrogen evolution.

Nature communications·2026

Same journal

metilene<sup>3</sup>: identifying DMRs across multiple conditions with auto-classification.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 14, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

A Soft-Robotic Biomimetic Benchtop Model for Esophageal Motility Simulation.

Seán Kilroy^1,2, Neelesh A Patankar³, Walter W Chan²

¹School of Mechanical & Materials Engineering, UCD Centre for Biomedical Engineering, UCD Conway Institute, University College Dublin, Dublin, Ireland.

Nature Communications

|March 13, 2026

Summary

This summary is machine-generated.

A new soft-robotic model, RoboGullet+, accurately simulates esophageal motility and swallowing dysfunction. This advanced tool aids in understanding achalasia and optimizing dietary recommendations for patients.

More Related Videos

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Published on: May 9, 2017

Related Experiment Videos

Last Updated: Mar 14, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Cardiac Muscle Cell-based Actuator and Self-stabilizing Biorobot - Part 2

Published on: May 9, 2017

Area of Science:

Biomedical Engineering
Gastroenterology
Robotics

Background:

Current large animal and benchtop models inadequately represent the esophageal environment and cannot simulate swallowing dysfunction (dysphagia).
Limitations hinder progress in understanding esophageal motility disorders like achalasia and developing evidence-based dietary advice.

Purpose of the Study:

To develop and validate RoboGullet+, a biomimetic soft-robotic platform capable of simulating normal and diseased esophageal motility.
To assess the platform's utility in evaluating stent migration, simulating achalasia subtypes, and analyzing bolus swallowing.

Main Methods:

Development of RoboGullet, a soft-robotic model with independent longitudinal and circumferential muscle actuation.
Enhancement to RoboGullet+ incorporating porcine esophageal mucosa/submucosa for biohybrid realism.
Application testing for stent migration, achalasia simulation (Types I-III), and bolus transit analysis.

Main Results:

Stent migration increased over fivefold with longitudinal muscle movement compared to circumferential alone.
Viscous non-Newtonian bolus improved high-resolution manometry sensitivity for Achalasia III by increasing Distal Latency by 20.83%.
Stirred Greek-style yoghurt significantly improved bolus transit for Achalasia Types I-II patients compared to unstirred.

Conclusions:

RoboGullet+ provides a versatile and realistic simulation of esophageal function and dysfunction.
The platform advances understanding of esophageal motility disorders and therapeutic interventions.
Findings support the use of specific bolus properties and dietary modifications for achalasia management.