Related Experiment Video
Updated: Mar 14, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Mendelian randomization reveals DNA methylation-related pyroptosis genes associated with psoriasis risk
1Department of Dermatology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
Background:
Research has indicated a connection between pyroptosis and psoriasis, yet the specific genes involved remain largely unidentified. This study employed Mendelian randomization (MR) to evaluate the potential causal impact of both pyroptosis-related genes and DNA methylation signatures on psoriasis risk.
Methods:
Pyroptosis-related genes were sourced from the GeneCards database. We integrated quantitative trait locus (QTL) data, including expression (eQTLs), DNA methylation (mQTLs), and protein expression (pQTLs). The GCST90014456 database provided genome-wide association study (GWAS) data for psoriasis, using the FinnGen and UKB cohorts for validation. Summary data-based Mendelian randomization (SMR) analysis assessed interactions between these genes and psoriasis, while colocalization analysis identified shared causal genetic variants.
Results:
SMR analysis identified 82 methylation sites, 18 gene, and 2 protein were associated with psoriasis risk. Multi-omics integration highlighted ADAR, which increased methylation at cg27530370 was associated with decreased ADAR expression (OR = 0.505, 95% CI [0.421-0.607]). Additionally, DNMT3B, PROM2, and KIF11 were the intersection genes of mQTL and eQTL analysis, and were validated by the UKB cohort in eQTL analysis, and NFKB1 was validated by the UKB cohort in pQTL analysis.
Conclusion:
This multi-omics analysis reveals that pyroptosis-related genes, particularly ADAR, DNMT3B, PROM2, KIF11, and NFKB1, may be involved in psoriasis development, providing important insights into its molecular mechanisms and potential therapeutic targets.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Pleiotropy
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu