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Delivery systems in the diagnosis and treatment of chronic atrophic gastritis: A Three-Level health strategy guided
Wenqian Xu1, Ping Gao1,2, Xiuxun Wu1
1School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065 China.
Introduction:
Chronic atrophic gastritis with accelerated progression represents a major risk factor for gastric cancer development, primarily driven by pathological processes including microbial imbalance, oxidative stress, chronic inflammation, immune dysregulation, mucin dynamics, and glycobiological disorders. Its global incidence is on the rise. Current diagnostic and therapeutic approaches under the reactive medicine paradigm demonstrate limited efficacy in controlling disease progression. Against this backdrop, supramolecular self-assembling delivery systems derived from herbal medicine offer breakthrough solutions to the current diagnostic and therapeutic challenges of chronic atrophic gastritis. Their advantages include natural origin, simple assembly, multi-target synergistic effects, high biocompatibility, and low potential toxicity.
Aims:
By summarizing the molecular mechanisms underlying chronic atrophic gastritis and the strengths and limitations of traditional Chinese and Western medical approaches, this study proposes the health benefits of herb-derived supramolecular self-assembling delivery systems for chronic atrophic gastritis under predictive, preventive, and personalized medicine (PPPM/3PM).
Results:
This review further proposes an innovative strategy within the PPPM/3PM framework, positioning the herb-derived supramolecular self-assembling delivery system as a predictive medical approach, a cost-effective preventive measure, and a tailored optimal treatment plan for patients with chronic atrophic gastritis across primary care (protecting susceptible populations from health deterioration to disease), secondary care (protecting affected populations from disease progression), and tertiary care (enhancing patient quality of life and reducing complications).
Conclusion And Recommendations:
Supramolecular self-assembling delivery systems derived from natural herbal medicines enable personalized prevention and treatment of chronic atrophic gastritis with superior cost-effectiveness compared to conventional reactive medicine.
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