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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.

Christopher Pope1, Priscilla Ahwin2, Nikhil Kota2

  • 1Department of Medicine, Cooper University Health Care, Camden, NJ, USA.

Journal of Clinical Medicine Research
|March 13, 2026
PubMed
Summary
This summary is machine-generated.

Sepsis patients with cancer (SCa) are older, more likely male, White, with lower BMI and TIA history, but less likely drug users or diabetic. SCa patients experience shorter hospital stays but higher overall mortality, with similar readmission and in-hospital death rates compared to sepsis patients without cancer (SnoCa).

Keywords:
Cancer and sepsisCancer length of stayCancer outcomeSepsisSepsis mortality

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Area of Science:

  • Medical research
  • Oncology
  • Infectious diseases

Background:

  • Cancer and its treatments heighten sepsis susceptibility.
  • The intricate relationship between cancer and sepsis necessitates understanding distinct risk factors and outcomes.
  • This study compares sepsis in cancer patients (SCa) versus non-cancer patients (SnoCa).

Purpose of the Study:

  • To elucidate differences in sepsis risk factors between SCa and SnoCa patients.
  • To compare outcomes, including mortality and length of stay, for SCa versus SnoCa patients.
  • To identify specific demographic and clinical characteristics associated with sepsis in cancer patients.

Main Methods:

  • Retrospective cohort analysis of adult sepsis patients in an urban tertiary healthcare center.
  • Comparison of risk factors and outcomes between SCa (n=310) and SnoCa (n=628) groups.
  • Statistical analyses including simple linear regression and logistic regression models.

Main Results:

  • SCa patients were older (66.8 vs. 61.5 years) and more frequently male, White, with lower BMI and TIA history.
  • SCa patients showed lower associations with recreational drug use and diabetes mellitus.
  • SCa group had a shorter length of stay (LOS) but increased odds of all-cause mortality (OR 1.82); readmission, bloodstream infection, and in-hospital mortality rates were comparable.

Conclusions:

  • Sepsis in cancer patients is associated with distinct demographic and clinical profiles compared to non-cancer patients.
  • While SCa patients have shorter LOS, they face higher overall mortality risks.
  • Key outcomes like readmissions and in-hospital mortality do not significantly differ between SCa and SnoCa groups.