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Updated: Mar 14, 2026

Automatic Identification of Dendritic Branches and their Orientation
Published on: September 17, 2021
Branched Schrödinger Bridge Matching
Sophia Tang1, Yinuo Zhang2, Alexander Tong3
1Department of Computer and Information Science, University of Pennsylvania.
None:
Predicting the intermediate trajectories between an initial and target distribution is a central problem in generative modeling. Existing approaches, such as flow matching and Schrödinger bridge matching, effectively learn mappings between two distributions by modeling a single stochastic path. However, these methods are inherently limited to unimodal transitions and cannot capture branched or divergent evolution from a common origin to multiple distinct modes. To address this, we introduce Branched Schrödinger Bridge Matching (BranchSBM), a novel framework that learns branched Schrödinger bridges. BranchSBM parameterizes multiple time-dependent velocity fields and growth processes, enabling the representation of population-level divergence into multiple terminal distributions. We show that BranchSBM is not only more expressive but also essential for tasks involving multi-path surface navigation, modeling cell fate bifurcations from homogeneous progenitor states, and simulating diverging cellular responses to perturbations.
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