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Drug-related problems in pediatric patients with chronic kidney disease: A single-center prospective study

Xingxing Liu1, Yue Li1, Zhen Mao1

  • 1Department of Pharmacy, Guiyang Maternal and Child Health Care Hospital, Guiyang Guizhou 550003, P.R. China.

Experimental and Therapeutic Medicine
|March 13, 2026
PubMed

Insights

Drug-related problems (DRPs) are common in pediatric patients with chronic kidney disease (CKD). A pharmacist-led approach using an adapted tool showed a high intervention acceptance rate for managing these issues in children.

Area of Science:

  • Pharmacology
  • Nephrology
  • Pediatrics

Background:

  • Limited data exists on drug-related problems (DRPs) in pediatric patients with chronic kidney disease (CKD) in China.
  • Understanding DRPs is crucial for optimizing pharmacotherapy in this vulnerable population.

Purpose of the Study:

  • To determine the incidence and determinants of DRPs in pediatric patients with CKD.
  • To inform evidence-based pharmacotherapy strategies for pediatric CKD patients.

Main Methods:

  • A single-center prospective study was conducted from January to December 2023.
  • The Pharmaceutical Care Network Europe (PCNE) taxonomy v9.1 was adapted for pediatric CKD patients.
  • DRPs were classified using the modified PCNE v9.1 tool.

Main Results:

  • Out of 383 hospitalized children with CKD, 136 (35.51%) experienced 203 DRPs.
  • Most DRPs related to treatment effectiveness (93.60%).
  • Drug selection was a significant contributing factor (35.43% of underlying causes).
  • Clinical pharmacists initiated 254 interventions, with 95.67% acceptance.

Conclusions:

  • DRPs are prevalent in pediatric CKD patients.
  • A pharmacist-led medication reconciliation model with an adapted PCNE tool achieved high intervention acceptance.
  • Further multi-center validation is needed to generalize findings on DRP identification and management.

Keywords:
Pharmaceutical Care Network Europechronic kidney diseasedrug-related problemsmedication reconciliationpediatric

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