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Hypertension as a Predictor of Ovarian Cancer Risk: A Systematic Review and Meta-Analysis.
Abdur Rahim1, Aftab Ullah2,3, Wahby Mohammed Babaresh4
1Department of Pharmacy CECOS University Peshawar Pakistan.
Health Science Reports
|March 13, 2026
Summary
This meta-analysis found no significant link between hypertension and ovarian cancer risk. Further research with larger groups and robust designs is needed to confirm these findings on high blood pressure and gynecological malignancies.
Area of Science:
- Gynecological Oncology
- Cardiovascular Epidemiology
- Cancer Risk Factors
Background:
- Ovarian cancer is a leading cause of cancer death in women globally.
- The association between hypertension and ovarian cancer risk is not well-established.
- This study investigates the potential link between high blood pressure and ovarian cancer incidence.
Purpose of the Study:
- To systematically review and meta-analyze observational studies on hypertension and ovarian cancer risk.
- To clarify the inconclusive evidence regarding this association.
- To provide updated insights for clinical and research communities.
Main Methods:
- Systematic literature search of PubMed, Embase, and Web of Science.
- Meta-analysis of 11 observational studies (2,523,751 participants) using random-effects model.
- Subgroup analyses by study design, parity, and BMI; heterogeneity assessed via I² statistic.
Main Results:
- No statistically significant association between hypertension and ovarian cancer risk (RR, 1.06; 95% CI, 0.96-1.20).
- Significant heterogeneity observed (I² = 81%).
- Parity showed a protective effect (RR, 1.43), while obesity (BMI ≥ 25) increased risk (RR, 1.12).
Conclusions:
- This meta-analysis indicates no statistically significant association between high blood pressure and ovarian cancer risk.
- Further large-scale studies with robust designs are necessary to validate these findings.
- Factors like parity and obesity may modulate ovarian cancer risk in hypertensive individuals.
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