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Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

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The MICH concept for long-term implant stability.

Abdusalam E Alrmali, Jonathan Misch, Ramon Gomez-Meda

    International Journal of Oral Implantology (Berlin, Germany)
    |March 13, 2026
    PubMed
    Summary

    The MICH concept offers a structured approach for long-term stability with tissue-level implants, focusing on mucosal seal and implant positioning. This evidence-based framework ensures better soft tissue integration and prosthetic success.

    Keywords:
    dental implantsimplant maintenanceimplant-supported prosthesisperi-implant tissue stability

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    Area of Science:

    • Dentistry
    • Biomaterials Science
    • Prosthodontics

    Background:

    • Achieving long-term stability in dental implants, particularly tissue-level systems, presents unique challenges.
    • Current literature and clinical guidelines require synthesis to address both soft tissue and prosthetic components.
    • Existing frameworks like PROS focus on bone-level implants, necessitating a tailored approach for tissue-level systems.

    Purpose of the Study:

    • To introduce a structured, evidence-based concept (MICH) for enhancing long-term soft tissue and prosthetic stability with tissue-level implants.
    • To synthesize current literature and clinical guidelines into actionable pillars for clinicians.
    • To provide clear guidance for interdisciplinary planning and promote peri-implant health.

    Main Methods:

    • Literature synthesis and clinical guideline analysis.
    • Development of a four-pillar concept (MICH): mucosal seal, individualized implant positioning, collar design optimization, and harmonized integration.
    • Adherence to Appraisal of Guidelines for REsearch & Evaluation (AGREE) standards.

    Main Results:

    • The MICH concept emphasizes a mucosal seal (≥ 2 mm thickness) to prevent marginal bone loss.
    • Highlights the importance of supracrestal tissue height adhesion for personalized implant placement and collar design.
    • Addresses both biological and prosthetic aspects, advancing beyond the PROS concept for bone-level implants.

    Conclusions:

    • The MICH concept provides a structured framework for optimizing tissue-level implant outcomes.
    • It aims to improve interdisciplinary planning and promote long-term stability of hard and soft tissues.
    • This approach offers clinicians clear guidance for managing the complexities of tissue-level implant systems.