Related Experiment Video
Updated: Mar 14, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Closing the Gap in Photoprotection: Implications for Skin of Colour in Australia
Sue Liu1, Samuel Morriss2, Peter Foley3,4,5
1St Vincent's Hospital, Melbourne, Victoria, Australia.
Abstract:
Long wave UVA1 is a critical driver of hyperpigmentation and skin aging in skin of colour. In combination with visible light, it shares a synergistic relationship in amplifying oxidative damage and hyperpigmentation in skin of colour. Disorders of hyperpigmentation affect a large proportion of Australians and have significant psychosocial burden. Photoprotection remains the mainstay of treatment by reducing severity and recurrence. UVA1 photoprotection is critical; however, existing sunscreens in Australia approved by the Therapeutic Goods Administration only provide limited protection, with no approved filters for UVA1 currently available. This review focusses on the critical role of UVA1, alongside other wavebands, in pigmentary disease and skin aging in skin of colour and the protective role of effective photoprotection. As the Australian population becomes increasingly ethnically diverse, it is vital that filters covering this critical waveband are incorporated into photoprotection to protect skin of colour.
Related Concept Videos
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Photoreceptors and Plant Responses to Light
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

