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Updated: Mar 14, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Humupulusones A and B, Two Skeletally Novel Acylphloroglucinol Derivatives from Humulus lupulus
Huaqiang Li1, Siqi Li1, Gang Li1
1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311403, China.
None:
Two novel acylphloroglucinol derivatives, humupulusones A and B (1 and 2), were isolated from Humulus lupulus. Compound 1, a pair of enantiomers (1a/1b), is the first acylphloroglucinol derivative with a bicyclo[2.2.2] carbon skeleton possessing a novel 5/6/6/5/5 ring system. Humupulusone B (2), a pair of hemiacetal tautomers, features a highly rearranged 5/6/5-fused tricyclic scaffold. Moreover, 1a and 2 exhibited significant inhibitory effects on LPS-induced NO production in BV-2 cells with IC50 values of 13.55 and 16.09 μM, respectively.
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