Asperiecolins A-D: Undescribed Variecolin-Type Sesterterpenoids with Anti-Inflammatory and AChE Inhibitory Activities
Jun Yao1, Jiangchun Wei2,3, Xingpiao Jin3
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, and Wuhan (China-Romania) Belt and Road Joint Laboratory on Traditional Chinese Medicine, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Abstract:
Four new sesterterpenoids, designated as asperiecolins A-D (1-4), were isolated from fungus Aspergillus sp. TJ403-YJ22. Asperiecolin A (1) possesses an unprecedented 5/8/6/6/5-fused pentacyclic framework with 11 stereocenters, while asperiecolins B (2) and C (3) feature an unusual five-membered lactam ring. All compounds inhibited LPS-induced NO and TNF-α production in macrophages. Additionally, compound 1 exhibited potent AChE inhibition (IC50 = 0.67 ± 0.05 μM), highlighting its therapeutic potential for inflammatory and neurodegenerative diseases.
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