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Related Concept Videos

Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

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The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
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Mechanism of Filopodia Formation01:39

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Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Actin Filament Depolymerization01:19

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Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
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Formation of Higher-order Actin Filaments01:11

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The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin...
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The Role of Actin and Myosin in Non-muscle Cells01:10

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Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
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Adaptability of Cytoskeletal Filaments01:12

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The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
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Related Experiment Video

Updated: Mar 15, 2026

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
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Nonreciprocal buckling makes active filaments polyfunctional.

Sami C Al-Izzi1,2,3, Yao Du4, Jonas Veenstra4

  • 1School of Physics, University of New South Wales, Sydney, NSW 2052, Australia.

Proceedings of the National Academy of Sciences of the United States of America
|March 13, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed self-snapping active filaments that move unidirectionally without external control. These free-standing structures use nonreciprocal interactions and critical exceptional points for robust propulsion, enabling functions like crawling and digging.

Keywords:
active matterautonomyexceptional physicsmultistabilitysoft robotics

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Area of Science:

  • Physics
  • Materials Science
  • Robotics

Background:

  • Active filaments are crucial for propulsion and actuation in biological systems, soft robotics, and mechanical metamaterials.
  • Existing artificial active rods lack robustness and adaptability due to reliance on external control or substrate tethering.

Purpose of the Study:

  • To demonstrate large-scale unidirectional dynamics in free-standing active filaments using nonreciprocal interactions.
  • To bypass limitations of external control and substrate dependence in artificial active rods.

Main Methods:

  • Coupling antisymmetrical bending modes of a buckled beam to induce self-snapping.
  • Utilizing a critical exceptional point where bending modes become simultaneously unstable and degenerate.
  • Observing dynamics in free-standing slender structures without external control.

Main Results:

  • Transformed multistable dynamics of elastic snap-through into persistent cycles of shape change.
  • Achieved self-snapping transition mediated by a critical exceptional point.
  • Demonstrated active filaments exploiting self-snapping for crawling, digging, and walking upon environmental perturbation.

Conclusions:

  • Nonreciprocal interactions enable robust, adaptive, and large-scale unidirectional dynamics in free-standing active filaments.
  • Critical exceptional physics provides a framework for programming instabilities into functional active materials.
  • This approach offers a new paradigm for designing self-propelled and adaptive artificial structures.