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Updated: Mar 15, 2026

A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

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Peripheral Hypertrophic Subepithelial Corneal Degeneration.

Adam Wylęgała¹, Claudia Azzaro², Patrycja Potrawa³

¹Experimental Ophthalmology Unit, Department of Biophysics, Division of Dentistry, II School of Medicine, Zabrze Medical University of Silesia, 40-752 Katowice, Poland.

Journal of Clinical Medicine

|March 14, 2026

Summary

This summary is machine-generated.

Peripheral hypertrophic subepithelial corneal degeneration (PHSCD) primarily affects middle-aged women, causing corneal changes and astigmatism. A link to thyroid disease, like Hashimoto's, suggests an immune basis for this rare condition.

Keywords:

corneal astigmatism corneal imaging corneal topography optical coherence tomography peripheral hypertrophic subepithelial corneal degeneration

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Published on: November 22, 2024

Area of Science:

Ophthalmology
Corneal Diseases
Immunology

Background:

Peripheral hypertrophic subepithelial corneal degeneration (PHSCD) is a rare corneal condition.
Understanding its clinical features and potential systemic associations is crucial for diagnosis and management.

Purpose of the Study:

To characterize the clinical features, corneal topography, and imaging findings of PHSCD.
To evaluate potential associations between PHSCD and systemic conditions.

Main Methods:

Comprehensive ophthalmic examination, anterior segment photography, and high-resolution spectral-domain optical coherence tomography (OCT).
Corneal topography/tomography, patient demographics, ocular history, and systemic conditions were analyzed.
In vivo confocal microscopy was used in a subset of patients.

Main Results:

PHSCD predominantly affected middle-aged females (11/14).
OCT revealed subepithelial fibrosis in the superior-nasal quadrants, leading to corneal flattening and astigmatism.
Five patients had Hashimoto's disease, and two had hyperthyroidism, suggesting a potential link to thyroid disorders.

Conclusions:

PHSCD presents with peripheral subepithelial fibrosis, causing significant corneal thickness variations and astigmatism.
The association with thyroid disorders suggests a possible immunological component in PHSCD pathogenesis.
Advanced imaging techniques like OCT and confocal microscopy are valuable for diagnosing and characterizing PHSCD.