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Updated: Mar 15, 2026

Evaluating the Function of the Foot Core System in the Elderly
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Burning Issues/Hot Topics: The Charcot Foot.

Victoria E L Milbourn1,2,3, Ava Khoshnaghsh4, Michael E Edmonds3,5

  • 1Department of Rehabilitation Medicine, Amsterdam University Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Journal of Clinical Medicine
|March 14, 2026
PubMed
Summary
This summary is machine-generated.

Charcot neuro-osteoarthropathy, a severe diabetic neuropathy complication, requires early recognition to prevent limb-threatening deformities. Prompt diagnosis and multidisciplinary care are crucial for managing this condition effectively.

Keywords:
Charcot neuro-osteoarthropathyclinical managementdiabetic neuropathy

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Area of Science:

  • Diabetology
  • Orthopedics
  • Neurology

Background:

  • Charcot neuro-osteoarthropathy is a severe complication of diabetic neuropathy.
  • It can lead to rapid deformity, ulceration, and limb loss.
  • Early signs are often subtle and missed, delaying critical intervention.

Purpose of the Study:

  • To provide a comprehensive overview of Charcot foot.
  • To integrate clinical presentation, diagnosis, and management strategies.
  • To highlight challenges in monitoring disease activity and emphasize multidisciplinary care.

Main Methods:

  • Review of current literature and clinical guidelines.
  • Integration of clinical observation and imaging analysis.
  • Discussion of differential diagnosis and management approaches.

Main Results:

  • Early recognition is key to preventing irreversible structural changes.
  • Diagnostic pathways combine clinical assessment with detailed imaging.
  • Monitoring disease activity, including remission and relapse, presents challenges.

Conclusions:

  • Structured assessment and targeted interventions improve care for Charcot neuro-osteoarthropathy.
  • Timely specialist referral and multidisciplinary management are essential.
  • Evidence-informed care is vital for patients with this condition.