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Updated: Mar 15, 2026

Evaluating the Function of the Foot Core System in the Elderly
Published on: March 11, 2022
Burning Issues/Hot Topics: The Charcot Foot
Victoria E L Milbourn1,2,3, Ava Khoshnaghsh4, Michael E Edmonds3,5
1Department of Rehabilitation Medicine, Amsterdam University Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
None:
Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This article provides a comprehensive overview of the Charcot foot, integrating clinical presentation, differential diagnosis and current approaches to investigation and management. It also highlights the challenges of monitoring disease activity over time, including remission and relapse, and the importance of timely specialist referral and multidisciplinary management. By reinforcing structured assessment and targeted intervention, this review aims to support consistent, evidence-informed care for people affected by Charcot neuro-osteoarthropathy.
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