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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Related Experiment Video

Updated: Mar 15, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

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Published on: August 22, 2016

Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized,

Young In Lee^1,2, Nam Hao Chau³, Ngoc Ha Nguyen^1,3

¹Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

International Journal of Molecular Sciences

|March 14, 2026

Summary

Particulate human acellular dermal matrix (phADM) offers a durable solution for skin rejuvenation, outperforming hyaluronic acid in improving skin density, elasticity, and hydration. This injectable scaffold promotes natural tissue repair with a strong safety profile.

Keywords:

acellular dermal matrix dermal fillers extracellular matrix regenerative medicine skin aging skin boosters

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Area of Science:

Biomaterials Science
Dermatology
Regenerative Medicine

Background:

Current injectable skin boosters offer limited duration or rely on inflammation, posing safety and efficacy concerns.
Particulate human acellular dermal matrix (phADM) is an injectable extracellular matrix scaffold designed for constructive dermal remodeling.

Purpose of the Study:

To evaluate the efficacy and safety of phADM as a facial skin booster compared to hyaluronic acid (HA).
To assess the mechanisms underlying phADM's skin rejuvenating effects.

Main Methods:

A 20-week, randomized, split-face, double-blinded clinical trial in 20 adults with moderate cheek roughness.
Assessment of skin parameters using imaging and biophysical instruments.
Mechanistic validation through in vitro, ex vivo human skin, and in vivo rat models.

Main Results:

phADM demonstrated superior improvements in skin density, volume, elasticity, wrinkle depth, pore area, hydration, and barrier function compared to HA.
Ex vivo studies showed homogeneous distribution and ECM preservation with phADM.
In vivo and in vitro studies indicated fibroblast infiltration, neocollagenesis, enhanced ECM synthesis, and anti-inflammatory effects.

Conclusions:

phADM acts as a restorative skin booster, promoting durable dermal remodeling and functional rejuvenation.
phADM exhibits a favorable safety profile, with no serious adverse events observed.