Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.7K
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Mineral Surfaces to Peptides: Hydroxyapatite-Based Platforms for Surface-Mediated Prebiotic Synthesis.

International journal of molecular sciences·2026
Same author

Designing Multifunctional Antibacterial Hydrogels: A Tri-Pillar Approach Based on Bacteriophages, Hydroxyapatite, and Electrospun Systems.

Gels (Basel, Switzerland)·2026
Same author

The Art of PEGylation: From Simple Polymer to Sophisticated Drug Delivery System.

International journal of molecular sciences·2025
Same author

Electrospun antimicrobial poly(lactic acid) foams with nanocellulose for enhanced hydrophilicity and controlled drug release.

RSC advances·2025
Same author

Characterization and Biomedical Applications of Electrospun PHBV Scaffolds Derived from Organic Residues.

International journal of molecular sciences·2025
Same author

PEGylated Micro/Nanoparticles Based on Biodegradable Poly(Ester Amides): Preparation and Study of the Core-Shell Structure by Synchrotron Radiation-Based FTIR Microspectroscopy and Electron Microscopy.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Mar 15, 2026

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

9.5K

From Nanoparticle Design to Clinical Translation in Cancer Therapy.

Jordi Puiggalí1

  • 1Departament de Enginyeria Química, Escola d'Enginyeria de Barcelona Est, Universitat Politècnica de, Catalunya, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.

International Journal of Molecular Sciences
|March 14, 2026
PubMed
Summary

Nanoparticle-based cancer therapies integrate material science and immunology for advanced treatment. This review covers nanoparticle platforms, targeting strategies, and overcoming tumor barriers for improved cancer nanomedicine.

Keywords:
bioinspired nanomaterialscancer immunotherapycancer therapydrug deliveryhydroxyapatiteinorganic nanoparticleslipid nanoparticlesmRNA deliverynanomedicinenanoparticlespolymeric nanoparticlestargeting strategiestranslational nanomedicinetumor microenvironment

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.7K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.2K

Related Experiment Videos

Last Updated: Mar 15, 2026

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

9.5K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.7K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.2K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cancer Biology
  • Immunology

Background:

  • Nanoparticle-based strategies are revolutionizing cancer therapy by merging diverse scientific fields.
  • Recent advances enable nanoparticles for active targeting, environmental responsiveness, and immune system modulation.

Purpose of the Study:

  • To provide a comprehensive overview of nanoparticle platforms for cancer treatment.
  • To discuss structure-property relationships, biological interactions, and targeting strategies.
  • To analyze nanoparticle capabilities in overcoming tumor microenvironment barriers.

Main Methods:

  • Review of major nanoparticle platforms: lipid-based, polymeric, inorganic, and bioinspired.
  • Analysis of passive, active, stimuli-responsive, and immune-mediated targeting strategies.
  • Examination of nanoparticle applications in cancer immunotherapy, including vaccines and mRNA systems.

Main Results:

  • Nanoparticles offer versatile platforms for drug delivery, targeting, and immunotherapy.
  • Effective strategies exist to overcome tumor microenvironment challenges like hypoxia and immunosuppression.
  • Nanoparticle-enabled immunotherapy shows promise, especially mRNA-lipid nanoparticle systems.

Conclusions:

  • Nanoparticle design and biological interactions are crucial for effective cancer therapy.
  • Overcoming translational challenges like safety, toxicity, and manufacturing is key for clinical impact.
  • Biologically informed design and regulatory considerations are vital for next-generation cancer nanomedicine.