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Related Concept Videos

Pulse rhythm01:30

Pulse rhythm

1.6K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
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Related Experiment Video

Updated: Mar 15, 2026

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
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A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

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First-in-Human Prospective, Observational, and Comparative Clinical Study of Simultaneous Invasive and Non-Invasive

Indre Lapinskiene1,2, Edvinas Chaleckas3, Vilma Putnynaite3

  • 1Clinic of Anaesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.

Sensors (Basel, Switzerland)
|March 14, 2026
PubMed
Summary

A new non-invasive system accurately monitors intracranial pressure (ICP) waveforms using eyeball movement. This breakthrough offers a safer alternative to invasive methods for neurocritical care, potentially improving patient outcomes.

Keywords:
intracerebral hemorrhageintracranial complianceintracranial pressurenon-invasive monitoringsubarachnoid hemorrhagetraumatic brain injury

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Area of Science:

  • Neurosurgery
  • Biomedical Engineering
  • Critical Care Medicine

Background:

  • Invasive intracranial pressure (ICP) monitoring is crucial for neurocritical care but carries significant risks like infection and hemorrhage.
  • ICP waveform morphology offers valuable insights beyond mean ICP, yet non-invasive monitoring remains a challenge.
  • Existing non-invasive methods lack the accuracy and reliability needed for widespread clinical adoption.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of a novel, non-invasive ICP pulse waveform monitoring system (Archimedes 02).
  • To compare the performance of the non-invasive system against established invasive ICP monitoring methods.
  • To determine if the non-invasive signal primarily reflects ICP dynamics or arterial blood pressure.

Main Methods:

  • A prospective, first-in-human comparative clinical study involving 15 intensive care unit patients.
  • Simultaneous acquisition of non-invasive ICP pulse waveforms (Archimedes 02), invasive ICP waveforms, and invasive radial artery blood pressure (ABP) waveforms over 3-minute sessions.
  • Graphical and correlation analysis of averaged waveforms to assess signal fidelity and specificity.

Main Results:

  • The Archimedes 02 system demonstrated a strong correlation with invasive ICP waveforms (R¯ = 0.965).
  • Correlations between non-invasive ICP and ABP (R¯ = 0.699), and invasive ICP and ABP (R¯ = 0.749) were significantly lower, indicating signal specificity.
  • The non-invasive signal was found to primarily reflect ICP dynamics, distinguishing it from arterial blood pressure variations.

Conclusions:

  • The novel non-invasive ICP monitoring system shows high accuracy and feasibility in a first-in-human study.
  • This technology has the potential to significantly enhance neurocritical care by providing a safer alternative to invasive monitoring.
  • Further validation in larger, diverse patient populations is recommended to support broader clinical implementation.