Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

6.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
Autophagic Cell Death01:18

Autophagic Cell Death

4.9K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.9K
Mitochondria01:37

Mitochondria

21.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.2K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

10.4K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
10.4K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

5.5K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
5.5K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

13.6K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Risk factors on the unintentional injuries among rural children aged 0-12 in Shaanxi province].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2013
Same author

Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment.

Depression and anxiety·2013
Same author

Current status and challenge of Human Parasitology teaching in China.

Pathogens and global health·2012
Same author

Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes.

Biotechnology advances·2012
Same author

Surgical treatment of ossification of the ligamentum flavum associated with dural ossification in the thoracic spine.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2012
Same author

Broadband focusing ultrasonic transducers based on dimpled LiNbO3 plate with inversion layer.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2012

Related Experiment Video

Updated: Mar 16, 2026

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
07:56

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome

Published on: November 30, 2022

6.4K

Nanomaterials regulate cellular functions and influence cell fate through mitophagy.

Yan Wang1, Da Li1, Zhen Ai1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou 510280, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 14, 2026
PubMed
Summary

Nanomaterials can modulate mitophagy, a cellular process vital for health. This review explores how nanomaterials regulate mitophagy for disease intervention while addressing biosafety concerns.

Keywords:
Cell fate regulationMitophagyNanomaterial-based therapyNanomaterialsRedox balance

More Related Videos

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
09:13

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

15.9K
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
08:40

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

Published on: November 22, 2017

18.5K

Related Experiment Videos

Last Updated: Mar 16, 2026

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome
07:56

Visualizing Mitophagy with Fluorescent Dyes for Mitochondria and Lysosome

Published on: November 30, 2022

6.4K
Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
09:13

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

15.9K
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
08:40

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

Published on: November 22, 2017

18.5K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Nanotechnology

Background:

  • Mitophagy is essential for mitochondrial quality control, energy metabolism, and redox balance.
  • Dysregulated mitophagy is linked to metabolic disorders and abnormal cell fate.
  • Nanomaterials offer versatile tools for modulating mitophagy due to their designability and targeting capabilities.

Purpose of the Study:

  • To review recent advances in nanomaterial-mediated mitophagy regulation.
  • To explore the roles of nanomaterials in modulating mitophagy for cellular functions and disease models.
  • To provide a framework for understanding nanomaterial-mitophagy interactions and guide future nanomedicine design.

Main Methods:

  • Literature review of recent studies on nanomaterials and mitophagy.
  • Analysis of signaling pathways involved in nanomaterial-mediated mitophagy.
  • Synthesis of information on the application of nanomaterials in disease models related to mitophagy.

Main Results:

  • Nanomaterials can bidirectionally regulate mitophagy, impacting energy metabolism, oxidative stress, senescence, and cell death.
  • Moderate mitophagy activation by nanomaterials can be therapeutic, while excess or impaired mitophagy can be detrimental.
  • Understanding these mechanisms is crucial for developing safe and effective nanomedicine.

Conclusions:

  • Nanomaterials show significant potential for therapeutic modulation of mitophagy.
  • Further research is needed to fully elucidate the bidirectional mechanisms and biosafety of nanomaterial-mitophagy interactions.
  • This review provides insights for designing advanced nanomedicines for metabolic and cell fate-associated diseases.