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Related Concept Videos

Mismatch Repair

Mismatch Repair

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Mismatch Repair

Mismatch Repair

Proofreading

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...

Proofreading

Proofreading

Base-pairing and DNA Repair

Base-pairing and DNA Repair

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Related Experiment Video

Updated: Mar 16, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

Comparison of state-of-the-art error-correction coding for sequence-based DNA data storage.

Andreas L Gimpel¹, Alex Remschak¹, Wendelin J Stark¹

¹Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland.

Nature Communications

|March 15, 2026

Summary

This summary is machine-generated.

This study benchmarks DNA data storage codecs, showing they tolerate high error rates. Realistic conditions enable densities up to 117 EB g^-1, demonstrating mature error correction for DNA storage.

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Last Updated: Mar 16, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

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Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

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Published on: September 13, 2018

Area of Science:

Biotechnology
Information Science
Genomics

Background:

Numerous DNA data storage codecs exist, but their performance lacks systematic benchmarking.
Error-correction is crucial for reliable DNA data storage.

Purpose of the Study:

To systematically benchmark representative DNA data storage codecs.
To establish the current state-of-the-art in codec performance.
To assess feasibility of high-density DNA data storage.

Main Methods:

In silico and in vitro experiments were used to compare six codecs.
Codec performance was evaluated under isolated and realistic conditions.
Experimental verification used synthesis by material deposition and electrochemical synthesis.

Main Results:

Individual codecs tolerate up to 14% error rates and 65% sequence loss.
Storage densities of 117 EB g^-1 are feasible under realistic conditions.
Experimental storage densities reached 43 EB g^-1 (material deposition) and 13 EB g^-1 (electrochemical synthesis).

Conclusions:

Error-correction coding for DNA data storage is mature.
The study defines the state-of-the-art for DNA data storage codecs.
Best practices for codec benchmarking in DNA data storage were established.